A Phase II Study of Emavusertib in Combination With an Approved Bruton Tyrosine Kinase Inhibitor in Patients With Chronic Lymphocytic Leukemia and Other B-cell Malignancies

Study Identifier:
CA-4948-203
CT.gov Identifier:
NCT07271667
EudraCT Identifier:
202552360068
EU Trial (CTIS) Number:
2025-523600-68-00
Study Contact Information:
(210) 593-5651 or [email protected]
Recruiting

Considering participating in a START clinical trial?

Get Started

Study Summary

The primary objective of the study for Cohort 1 and Cohort 2 is to assess the anticancer activity of emavusertib in combination with zanubrutinib in participants with CLL.

Medical Condition
The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.
Leukemia
Phase
The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
II
Sex
Female & Male
Age
18+ years
Study Drug
Drug: EXPERIMENTAL: Cohort 1: Emavusertib and Zanubrutinib
Read More
Drug: Participants in Cohort 1 include CLL participants who have been on zanubrutinib for at least 12 months and are currently in a partial response (PR) or partial response with lymphocytosis (PR-L) and measurable residual disease positive (MRD+). In Part A, participants will receive one of two doses of emavusertib twice daily (BID) and an approved dose of zanubrutinib per label. In Part B, additional participants will be enrolled in an expansion if pre-defined criteria for Part A are met. Participants will receive one of two doses of emavusertib BID and an approved dose of zanubrutinib per label.
Drug: Drug: Emavusertib
Drug: Oral tablets
Drug: Drug: Zanubrutinib
Drug: Oral capsules
Drug: Other Names: BRUKINSA®
Drug: EXPERIMENTAL: Cohort 2: Emavusertib and Zanubrutinib
Drug: Participants in Cohort 2 include relapsed CLL participants who have directly progressed on zanubrutinib after a confirmed response (PR or better lasting 6 months or longer). In Part A, participants will receive one of two doses of emavusertib BID and an approved dose of zanubrutinib per label. In Part B, additional participants will be enrolled in an expansion if pre-defined criteria for Part A are met. Participants will receive one of two doses of emavusertib BID and an approved dose of zanubrutinib per label.
Study Status
Indicates the current recruitment status or the expanded access status
Recruiting

Requirements information
Inclusion criteria
  • Inclusion Criteria (All Parts):
  • 1. Males and females ≥ 18 years of age.
  • 2. Life expectancy of ≥ 3 months.
  • 3. Eastern Cooperative Oncology Group Performance Status of 0, 1, or 2.
  • 4. Histopathologically confirmed diagnosis of CLL (medical record is acceptable), as per the World Health Organization 2016 classification.
  • 5. At least 1 criterion for measurable disease per International Workshop on Chronic Lymphocytic Leukemia (iwCLL).
  • 6. For Cohort 1 only:
  • 1. Participant must be in a partial response (PR) or partial response with lymphocytosis (PR-L) and measurable residual disease positive (MRD+) per Hallek et al, (2018) criteria.
  • 2. Participant must have detectable measurable residual disease (MRD) as determined by the ClonoSEQ assay
  • 3. Must be actively taking zanubrutinib for at least 12 months.
  • 4. Acceptable organ function at Screening within 28 days prior to Cycle 1 Day 1 (C1D1)
  • 7. For Cohort 2 only:
  • 1. Relapsed disease for which participants are ineligible for or have exhausted standard therapeutic options that would be considered standard of care
  • 2. Must be actively taking zanubrutinib.
  • 3. Participants must have had direct progression on zanubrutinib (within 3 months prior to study entry; administered as monotherapy or in combination) and no other anticancer therapy administered since.
  • 4. Acceptable organ function at Screening within 28 days prior to C1D1.
  • 8. Creatine phosphokinase (CPK) < 2.5 × ULN.
  • 9. Ability to tolerate a contrast-enhanced computed tomography (CT) scan.
  • 10. Ability to swallow and retain oral medications.
  • 11. Negative serum pregnancy test in women of childbearing potential (WOCP).
  • 12. WOCP and men who partner with WOCP must agree to use highly effective contraceptive methods for the duration of the study and for 180 days after the last dose of study treatment.
  • 13. Ability to understand and willingness to sign a written informed consent document. Legally authorized representatives may sign and give informed consent on behalf of study participants.
Exclusion criteria
  • (All Parts):
  • 1. Active second malignancy unless in remission with a life expectancy of > 2 years and with documented Sponsor approval.
  • 2. Active malignancy other than CLL requiring systemic therapy (exceptions may be granted following a discussion with the Sponsor Medical Monitor).
  • 3. Have high-risk CLL TP53 mutations and 17P deletion.
  • 4. History of Grade ≥ 3 rhabdomyolysis without complete recovery.
  • 5. Received prior chimeric antigen receptor-T cell therapy.
  • 6. Received prior investigational drugs (including treatment in clinical research, unapproved combination products, and new dosage forms) within 28 days or 5 half-lives, whichever is shorter, prior to C1D1; allogeneic hematopoietic stem cell transplant (HSCT) within 60 days prior to C1D1; or had clinically significant graft-versus-host disease (GVHD) requiring ongoing uptitration of immunosuppressive medications prior to Screening.
  • 7. Any prior systemic anticancer treatment such as chemotherapy, immunomodulatory drug therapy, etc., received within 21 days or 5 half-lives, whichever is shorter, prior to C1D1 (with the exception of zanubrutinib, which may be continued until the day before C1D1).
  • 8. Receiving the following medications within 7 days or 5 half-lives, whichever is shorter, prior to C1D1:
  • 1. Medications that, in the opinion of the Investigator, have a high risk of causing prolonged QT interval, corrected (QTc) and/or Torsades de Pointes.
  • 2. Peg-filgrastim or equivalent.
  • 3. St John's Wort.
  • 9. History of or ongoing drug-induced pneumonitis.
  • 10. History of stroke or intracranial hemorrhage within 6 months prior to C1D1. Participants with post-biopsy hemorrhagic sequela defined as a small hyperdense lesion < 3 millimeters (mm) on T2 sequence will not be excluded.
  • 11. Requirement for anticoagulation with warfarin or equivalent vitamin K antagonists, including dual antiplatelet agents, within 5 half-lives of the anticoagulant or 7 days, whichever is longer, prior to C1D1. Low molecular weight heparin is allowed. Participants who require the use of antiplatelet agents should be discussed with the Sponsor Medical Monitor (e.g., use of factor Xa inhibitors).
  • 12. Vaccinated with a live-attenuated vaccine within 4 weeks prior to C1D1.
  • 13. Prior history of hypersensitivity or anaphylaxis to emavusertib, zanubrutinib, or any of their excipients.
  • 14. Prior history of Stevens-Johnson syndrome or toxic epidermal necrolysis.
  • 15. Intolerance to contrast-enhanced CT scan due to allergic reactions to contrast agents.
  • 16. Major surgery < 28 days prior to C1D1; minor surgery < 7 days prior to C1D1.
  • 17. Viral infections:
  • 1. Known to be human immunodeficiency virus (HIV) positive or have an acquired immunodeficiency syndrome (AIDS)-related illness. If HIV is undetectable or maintained on treatment, enrollment may be allowed after discussion with the Sponsor Medical Monitor.
  • 2. Hepatitis B virus (HBV) deoxyribonucleic acid (DNA) positive or hepatitis C virus (HCV) infection < 6 months prior to C1D1, unless viral load is undetectable, or HCV with cirrhosis.
  • 3. Active systemic infection, including HIV, cytomegalovirus infection, or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, or has had, within 28 days prior to C1D1, an infection (other than nail trichophytosis) that requires hospitalization or an intravenous antibiotic.
  • 18. Concomitant illness that would preclude safe participation in the study.
  • 19. Pregnant or lactating female.

Clinical Study Information for Healthcare Providers

By clicking the button below you will find in-depth information about this clinical trial, including study design, primary and secondary endpoints, and more. This information is intended for healthcare professionals seeking to review the scientific and operational aspects of the study.

View Study Information

Study Locations

Location
Investigator
Status
Condition(s) Treated at Site
Location
START Madrid, Spain (FJD)
Madrid, Spain, 28040
Investigator
Status
Will Be Recruiting
Condition(s) Treated at Site
Leukemia