An Open-label, Multi-center, Global Phase II Clinical Study to Evaluate the Efficacy and Safety of HLX43 (Anti-PD-L1 ADC) in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC)
Study Identifier:
HLX43-NSCLC201
CT.gov Identifier:
EudraCT Identifier:
N/A
EU Trial (CTIS) Number:
N/A
Study Contact Information:
Recruiting
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Study Summary
The study is being conducted to to explore the reasonable dosage and evaluate the efficacy, safety and tolerability of HLX43 (Anti-PD-L1 ADC) in Patients with Advanced Non-small Cell Lung Cancer (NSCLC)
To evaluate the efficacy and safety of HLX43 in advanced non-small cell lung cancer (NSCLC) patients. It consists of two parts: Part 1, which focuses on dose exploration to identify the optimal HLX43 dosage for Part 2.
Medical Condition
The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.
Non-Small Cell Lung Cancer
Phase
The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
II
Sex
Female & Male
Age
18+ years
Study Drug
Drug: Experimental: HLX43 DOSE 1 (2.0 mg/kg)
Read More
Drug: Experimental: HLX43 DOSE 2(2.5 mg/kg)
Drug: Experimental Drugs
Study Status
Indicates the current recruitment status or the expanded access status
Recruiting
Requirements information
Inclusion criteria
- Have a full understanding of the study content, process, and possible adverse reactions before the study, and sign the informed consent form (ICF); voluntarily participate in the study; be able to complete the study as per protocol requirements;
- Aged ≥ 18 years at the time of signing the ICF, male or female;
- Histologically or cytologically confirmed, locally advanced (stage IIIB/IIIC) or metastatic (stage IV) NSCLC not suitable for radical treatment (complete surgical resection, concurrent/sequential radio-chemotherapy) according to the Union for International Cancer Control and the American Joint Committee on Cancer (AJCC) TNM staging system (8th edition), and should meet the following criteria:
- Subjects without actionable genomic alterations (AGAs):
- Subjects with non-squamous NSCLC must have documented negative test results for EGFR and ALK alterations. If no prior test results for EGFR and ALK are available, subjects must undergo EGFR and ALK testing at the study site. For subjects with squamous NSCLC, EGFR and/or ALK testing is not required prior to enrollment if their status is unknown;
- No other known actionable genomic alterations, such as ROS1, NTRK, BRAF, MET exon 14 skipping, and RET;
- Prior standard treatment failure of ≥ 1 line, including at least anti-PD-(L)1 antibody and platinum-based chemotherapy;
- Subjects with AGAs:
- Previous test results confirming the presence of one or more actionable genomic alterations;
- Prior standard treatment failure of ≥ 1 line, including at least targeted therapy for driver gene alterations (patients with EGFR mutations must be previously treated with EGFR inhibitors) and platinum-based chemotherapy;
- At least one measurable lesion as per RECIST 1.1 within 4 weeks prior to randomization;
- Subjects who agree to provide archived tumor tissue specimens that meets the testing requirements (either from the most recent surgery or biopsy, preferably within 2 years) or agree to undergo a biopsy to collect tumor tissue for PD-L1 expression testing;
- The following conditions must be met in terms of the time of the first administration of the investigational product: at least 3 weeks (or 5 half-lives of the drug, whichever is shorter) from the previous major surgery, medical device treatment, locoregional radiotherapy (except for palliative radiotherapy for bone lesions), cytotoxic chemotherapy, immunotherapy, or biological product therapy; at least 2 weeks from the previous hormone therapy or small molecular targeted therapy; at least 1 week from the administration of the traditional Chinese medicine for anti-cancer indications or minor surgery; and recovery of treatment-induced AEs to Grade ≤ 1 (CTCAE v5.0, except for Grade 2 peripheral neurotoxicity and alopecia);
- ECOG PS score of 0-1 within 1 week prior to randomization;
- Life expectancy > 3 months;
- Adequate organ functions as confirmed by laboratory tests within 1 week prior to randomization (no blood transfusions or treatment with granulocyte colony-stimulating factor is allowed within 14 days prior to the first dose)
- Male and female subjects with child-bearing potential must agree to use at least one highly effective contraception method during the study and within at least 6 months after the last dose of the investigational product; female subjects of childbearing age must be negative for pregnancy test within 7 days prior to enrollment.
Exclusion criteria
- Histologically or cytologically confirmed tumor containing components of small cell lung cancer, neuroendocrine carcinoma, or sarcomatoid carcinoma;
- Prior treatment with any medication targeting topoisomerase I, including chemotherapy or ADCs;
- Radical radiation therapy within 3 months prior to the first dose;
- History of any second malignancy within 2 years prior to randomization, except for early-stage malignancies (carcinoma in situ or stage I tumors) that have received radical treatment, such as non-melanoma skin cancer, cervical carcinoma in situ, localized prostate cancer, ductal carcinoma in situ of the breast, and papillary thyroid carcinoma;
- History of adverse events leading to permanent discontinuation of immunotherapy, or occurrence of ≥ Grade 2 immune-related pneumonitis or myocarditis during prior immunotherapy;
- Presence of uncontrollable pleural effusion, pericardial effusion, or ascites requiring repeated drainage;
- Presence of spinal cord compression or clinically active metastases to central nervous system (referring to untreated or symptomatic metastases, or metastases requiring corticosteroids or anticonvulsants to control associated symptoms), carcinomatous meningitis. Subjects who have previously received treatment for brain metastases (such as whole brain radiotherapy or stereotactic brain radiotherapy) may be eligible, provided that they are clinically stable for at least 4 weeks with no imaging evidence of brain metastasis progression;
- Subjects with current or prior history of clinically significant pulmonary impairment due to pulmonary comorbidities, including but not limited to any underlying lung disease (e.g., pulmonary embolism within 3 months prior to the first dose, severe asthma, severe chronic obstructive pulmonary disease, restrictive lung disease, interstitial pneumonia, pneumoconiosis, drug-related pneumonitis, and pleural effusion within 3 months prior to the first dose), any autoimmune, connective tissue, or inflammatory disease that may involve the lungs (i.e., rheumatoid arthritis, Sjogren's syndrome, sarcoidosis), prior pneumonectomy that may interfere with the detection and management of suspected drug-related pulmonary toxicity, or history of with radiation pneumonitis within 6 months;
- Patients with any poorly-controlled cardiovascular and cerebrovascular clinical symptoms or diseases, including but not limited to: (1) NYHA Class II or greater heart failure or left ventricular ejection fraction (LVEF) < 50%; (2) unstable angina pectoris; (3) myocardial infarction or cerebrovascular accident within 6 months (except lacunar infarction, slight cerebral ischemia, or transient ischemic attack); (4) poorly controlled arrhythmia (including QTc intervals ≥ 470 ms) (QTc intervals are calculated by Fridericia's formula); (5) poorly-controlled hypertension (systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 100 mmHg after active treatment);
- Patients with active systemic infectious diseases requiring intravenous antibiotics within 2 weeks prior to randomization;
- Patients who have used moderate or potent CYP2D6 or CYP3A inhibitors or inducers within 2 weeks prior to randomization;
- Patients who have received systemic corticosteroids (prednisone > 10 mg/d or equivalent dose of similar drug) or other immunosuppressants within 2 weeks prior to randomization; Except: patients treated with topical, ocular, intra-articular, intranasal, and inhaled corticosteroids; short-term prophylactic use of corticosteroids for contrast agents, etc.;
- Patients with known active or suspected autoimmune diseases. Patients with autoimmune-related hypothyroidism and receiving thyroid hormone replacement therapy and those with type 1 diabetes mellitus controlled with insulin therapy are eligible to be enrolled;
- Patients who have received live vaccine or live attenuated vaccine within 4 weeks prior to randomization;
- Patients who are known to have anaphylaxis to macromolecular protein preparations/monoclonal antibodies or are allergic to any component in the formulation of the investigational product;
- Patients with active tuberculosis;
- Patients with a history of immunodeficiency, including human immunodeficiency virus (HIV)-positive or other acquired or congenital immunodeficiencies, or history of organ transplantation;
- Patients with active HBV or HCV infection or HBV/HCV co-infection;
- Pregnant or lactating women;
- Patients who are not suitable for participating in this clinical study due to any clinical or laboratory abnormalities or other reasons as assessed by the investigator.
- 1Tumor histology or cytology confirmed the presence of small cell lung cancer, neuroendocrine carcinoma, or sarcomatoid carcinoma;
- 2Patients who have received any drug treatment targeting topoisomerase I, including chemotherapy and ADC drugs;
- 3The imaging examination during the screening period shows that the patient has the following evidence: a. Imaging evidence of tumor invasion of large blood vessels or tumor invasion of important organs or the risk of esophageal tracheal fistula or esophageal pleural fistula; b. Tumor surrounds large blood vessels with vascular stenosis, or cavitation or necrosis in lung lesions, and the investigator determines that there is imaging evidence that entry into the study will cause bleeding risk;
- 4Received radical radiotherapy within 3 months before the first dose;
- 5Any history of a second malignancy within 2 years before randomization, except for early malignancies that have received radical treatment (carcinoma in situ or stage I tumors), such as non-melanoma skin cancer, carcinoma in situ of cervical cancer, localized prostate cancer, ductal carcinoma in situ of the breast, and papillary thyroid carcinoma;
- 6Previous immune-related adverse events of grade ≥ 3 during immunotherapy;
- 7The presence of uncontrolled pleural effusion, pericardial effusion, or ascites that requires repeated drainage;
- 8The presence of spinal cord compression or clinically active central nervous system metastases (referring to untreated or symptomatic metastases, or metastases requiring corticosteroids or anticonvulsants to control related symptoms), carcinomatous meningitis. Subjects who have previously received treatment for brain metastases (such as whole brain radiotherapy or stereotactic brain radiotherapy) can participate in the study, provided that they are clinically stable for at least 4 weeks and have no imaging evidence of brain metastasis progression;
- 9Subjects with clinically severe lung damage caused by complications of lung diseases in the past or currently, including but not limited to any underlying lung diseases (such as pulmonary embolism within 3 months before the first dose, severe asthma, severe chronic obstructive pulmonary disease, restrictive lung disease, interstitial pneumonia, pneumoconiosis, drug-related pneumonia, pleural effusion, etc.) or any autoimmune, connective tissue or inflammatory diseases that may involve the lungs (i.e. rheumatoid arthritis, Sjogren's syndrome, sarcoidosis, etc.), or previous pneumonectomy, etc., which may interfere with the detection and treatment of suspected drug-related pulmonary toxicity; Subjects with radiation pneumonitis within 6 months;
- 10Subjects have poorly controlled clinical cardiovascular symptoms or diseases, including but not limited to: (1) heart failure of NYHA grade II or above or left ventricular ejection fraction (LVEF) <50%; (2) unstable angina; (3) myocardial infarction or cerebrovascular accident within 6 months (excluding lacunar infarction, mild cerebral ischemia or transient ischemic attack); (4) poorly controlled arrhythmias (including QTc interval ≥ 470 ms) (QTc interval calculated by Fridericia formula); (5) poorly controlled hypertension (systolic blood pressure >150 mmHg and/or diastolic blood pressure >100 mmHg after active treatment);
- 11Active systemic infectious disease requiring intravenous antibiotic treatment within 2 weeks before randomization;
- 12Use of moderate or strong inhibitors or inducers of CYP2D6 or CYP3A within 2 weeks before randomization;
- 13Patients who have received systemic corticosteroids (prednisone 10mg/day or equivalent dose of similar drugs) or other immunosuppressive drugs within 2 weeks before randomization; excluding the following situations: treatment with topical, ocular, intra-articular, intranasal and inhaled corticosteroids; short-term use of corticosteroids for preventive treatment when contrast agents are used;
- 14The presence of known active or suspected autoimmune disease. However, patients with autoimmune-related hypothyroidism receiving thyroid hormone replacement therapy are allowed to participate in the study; patients with controlled type 1 diabetes receiving insulin therapy are allowed to participate in the study;
- 15Received live vaccine or live attenuated vaccine within 4 weeks before randomization;
- 16The subject is known to have had an allergic reaction to macromolecular protein preparations/monoclonal antibodies, or is allergic to the components of the test drug preparation;
- 17Have active pulmonary tuberculosis;
- 18Have a history of immunodeficiency, including positive human immunodeficiency virus (HIV) test, or other acquired or congenital immunodeficiency diseases, or a history of organ transplantation;
- 19Active HBV or HCV infection or HBV/HCV co-infection; Note: Patients with positive HBsAg or HBcAb test during the screening period need to undergo further HBV-DNA test. If the test result indicates < 500 IU/mL, < 2500 copies/mL, or < ULN, they can be included in the group. Patients with detectable HBV-DNA must agree to receive anti-HBV nucleoside (acid) analogue treatment during the trial. Patients with positive HCV antibody test need to undergo further HCV-RNA test. If the test result indicates < ULN, they can be included in the group. Patients with HBV/HCV co-infection (positive HBsAg or HBcAb test, combined with positive HCV antibody test) are excluded.
- 20Pregnant or breastfeeding women;
- twenty oneThe investigator believes that the subject is not suitable for participating in this clinical study due to any clinical or laboratory test abnormalities or other reasons.
Clinical Study Information for Healthcare Providers
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Study Locations
Location
Investigator
Status
Condition(s) Treated at Site
Location
START La Rioja
Logroño, La Rioja, Spain, 26006
Investigator
Maria de Miguel
Status
Recruiting
Condition(s) Treated at Site
Non-Small Cell Lung Cancer