A Phase I/IIa Study in 3 Parts (Phase Ia and Phase Ib - Dose Escalations and Phase IIa Expansion Cohorts) to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of MIV-818 in Patients With Liver Cancer Manifestations
Study Identifier:
MIV-818-101/201
CT.gov Identifier:
EudraCT Identifier:
EU Trial (CTIS) Number:
N/A
Study Contact Information:
Study Complete
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Study Summary
To assess safety and tolerability of MIV 818 as either monotherapy or in combination with 1) lenvatinib, a tyrosine kinase inhibitor used as a standard of care for the treatment of HCC or 2) pembrolizumab, a PD-1 inhibitor.
The purpose of this study is to evaluate the safety of MIV-818 in combination with pembrolizumab or lenvatinib, to investigate the body's response after receiving the respective combinations and to find the best dose (amount) of MIV-818 when used in the respective combinations.
To evaluate the safety and efficacy of fostrox in combination with Lenvima in patients for whom current first- or second-line treatment has proven ineffective or is not tolerable
Medical Condition
The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.
Phase
The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
I/II
Sex
Female & Male
Age
18+ years
Study Drug
Read More
Study Status
Indicates the current recruitment status or the expanded access status
Study Complete
Requirements information
Inclusion criteria
- Unless otherwise stated, inclusion criteria apply to all phases and cohorts in the study.
- Male or female > or = 18 years of age on the day of signing informed consent.
- Able to understand and voluntarily sign a written informed consent and is willing, and able, to comply with the protocol requirements.
- Must have measurable disease based on RECIST v1.1 as determined by the site study team. Must have at least 1 target lesion in the liver. Tumor lesions situated in a previously irradiated area are considered measurable if progression has been demonstrated in such lesions.
- Must have a Child-Pugh A status for Phase 1a and Phase 1b. SRC discretion to expand to include Child-Pugh B status for Phase 1a and Phase 1b. Must have a Child Pugh A or B status for Phase 2a. SRC discretion to restrict to Child Pugh A status for Phase 2a.
- Must have an ECOG performance status of 0 or 1 at Screening.
- Must have life expectancy of > 12 weeks in the investigator’s opinion.
- Must have ALT and AST < or = 5.0 × upper limit of normal (ULN) at Screening.
- Must have total bilirubin (TBil) < or = 3.0 mg/dL at Screening.
- Must have platelets > or = 75,000/mL at Screening.
- Must have adequate renal function with estimated creatinine clearance
- = 60 mL/min (based on Cockcroft and Gault formula or similar) at Screening
- Must have platelets = 75,000/mL at Screening.
- Must have International Normalized Ratio (INR) = 1.7 at Screening. Female who is postmenopausal, OR Female who is of childbearing potential (postmenarchal) who agrees to use a highly efficient method of contraception (ie, a method with less than 1% failure rate [eg, sterilization, hormone implants, hormone injections, intrauterine devices, or vasectomized partner or combined birth control pills]) from Screening until 90 days after the final dose of MIV-818.
- OR Male who agrees to use condoms from Screening until 90 days after the final dose of MIV-818.
- OR Male with a female partner of childbearing potential (WOCBP) who is using a highly efficient method of contraception as described above.
- WOCBP must have a negative serum pregnancy test at Screening and negative (serum or urine) pregnancy test within 72 h before the first study drug dose.
- Phase 1a and 1b specific Inclusion Criteria:
- Must have progressed on or are intolerant of standard therapy with:
- Histologically or cytologically confirmed HCC, including fibrolamellar HCC; patients with HCC that received their diagnosis according to the agreed international radiological guideline are also admissible upon agreement between the investigator and the medical monitor, or
- Histologically or cytologically confirmed iCCA, or
- Liver metastases from colon, rectal, or gastric solid tumors with limited extrahepatic tumor burden (any extrahepatic metastases should be limited to 1 other site and a maximum of 1 target lesion outside the liver).
- Phase 1b Monotherapy-specific Inclusion Criterion:
- Must have:
- Histologically or cytologically confirmed HCC, including fibrolamellar HCC; patients with HCC that received their diagnosis according to the agreed international radiological guideline are also admissible upon agreement between the investigator and the medical monitor, or
- Histologically or cytologically confirmed iCCA, or
- Liver metastases from solid tumors, with limited extrahepatic tumor burden (i.e. no brain or bone metastases), any extrahepatic metastases should be limited to 1 other site and a maximum of 1 target lesion outside the liver).
- Combination therapy-specific Inclusion Criterion:
- Must have histologically or cytologically confirmed HCC that is considered advanced or unresectable, i.e. not suitable for either surgery, radiofrequency ablation (RFA) or loco-regional therapies (patients with HCC that received their diagnosis according to the agreed international radiological guideline are also admissible upon agreement between the investigator and medical monitor). Patients with fibrolamellar HCC or a mixed HCC and iCCA will be excluded.
- Must have progressed on or are intolerant of 1or 2 lines of standard therapy for HCC (see also exclusion criterion no. 20) and are now candidates for lenvatinib or pembrolizumab treatment.
- Pts with histologically, radiologically, or cytologically confirmed HCC, Child-Pugh A, ≥18 years, ECOG PS ≤ 1 and adequate organ function were eligible
Exclusion criteria
- Tumor volume exceeding 50% of liver.
- History of previous malignancy within the last 5 years except basal cell carcinoma or carcinoma in situ in solid organ.
- Known CNS or brain metastases, unless previously treated and stable for 3 months.
- Ongoing significant disease other than target disease as judged by the investigator to compromise the patients' ability to complete this study.
- History of solid organ transplant or bone marrow transplant.
- Receiving immunosuppressive therapy including oral corticosteroids.
- Active hepatitis B (eg, hepatitis B surface antigen [HBsAg] reactive) and patients with active hepatitis C (eg, hepatitis C RNA is [qualitative] detected).
- Positive human immunodeficiency virus (HIV) infection.
- Poorly controlled ascites and/or requirement for therapeutic paracentesis more frequently than once every 3 months.
- Symptomatic encephalopathy within 3 months prior to Screening and/or requirement for medication for encephalopathy.
- Esophageal variceal bleeding within 2 weeks prior to Screening.
- Receiving prior anticancer therapy within 4 weeks prior to first dose of MIV-818.
- Receiving any other investigational agent within 4 weeks prior to Screening
- Enrolled in another clinical study with an investigational drug.
- Presence of residual toxicities of CTCAE Grade > 1 after prior anticancer therapy within 2 weeks of first treatment with MIV-818, except for alopecia.
- History of allergic reactions attributed to compounds of similar chemical or biological composition to MIV-818.
- HCC of diffuse infiltrative type.
- Receiving drugs that are extensively metabolized by cytochrome P450 (CYP) 3A4 that have a narrow therapeutic index. Drugs that are extensively metabolized by CYP3A4 that have a narrow therapeutic index must be discontinued 5 half-lives before first dose of MIV-818.
- Combination therapy-specific Exclusion Criteria:
- Patients are excluded from combination therapy parts of this study if any of the following criteria are met:
- Patients with a diagnosis of fibrolamellar HCC.
- Received >2 lines of therapy for the treatment of advanced HCC.
- Systolic blood pressure (BP) ≥160 mmHg or diastolic BP ≥100 mmHg despite optimal anti-hypertensive therapy and with no change in anti hypertensive agents within the last 1 week prior to Screening.
- Women who are breastfeeding.
- Bleeding disorders or receiving anti-coagulation drugs.
- Any interventional treatment for esophageal varices required within 28 days of study treatment.
- Hepatic encephalopathy in the last 6 months.
- QTc interval is greater than 480 milliseconds at Screening.
- Active autoimmune disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment.
- Has an active infection requiring systemic therapy.
- Exclusion criteria applicable to pembrolizumab cohort only:
- Diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to planned start of study therapy.
- Presence of known active tuberculosis (TB; Bacillus tuberculosis).
- Has received a live vaccine within 30 days of planned start of study therapy. Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist®) are live attenuated vaccines, and are not allowed.
- Known history of, or any evidence of active, non-infectious pneumonitis or has a history of (non-infectious) pneumonitis that required steroids or current pneumonitis.
- Exclusion criterion applicable to lenvatinib cohort only:
- Proteinuria > 1g / 24 hours. Patients with > 1+ proteinuria on dipstick testing will need a 24-hour urine protein measured to exclude proteinuria > 1g / 24 hours.
Clinical Study Information for Healthcare Providers
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Study Locations
Location
Investigator
Status
Condition(s) Treated at Site
Location
START Barcelona
Barcelona, Spain, 08023
Investigator
Tatiana Hernandez Guerrero
Status
Recruiting
Condition(s) Treated at Site
Liver
Bile Duct