A Phase I, Open-label, Dose Finding Study to Assess the Safety, Tolerability, PK, and Preliminary Efficacy of OBT076, a CD205-directed ADC, in Recurrent and/or Metastatic CD205+ Solid Tumors and CD205+ HER2-negative Metastatic Breast Cancer
Study Identifier:
OBT076-001
CT.gov Identifier:
EudraCT Identifier:
EU Trial (CTIS) Number:
Study Contact Information:
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Study Summary
To look at several dose levels of the OBT076 to find the highest dose level that is safe and well-tolerated (does not cause unacceptable side effects), and to examine the effects of the study drug in a small group of research participants. The study will also look at the effectiveness of OBT076 as an anti-cancer therapy.
The dose-escalation phase:
To investigate the safety, tolerability and pharmacokinetic profile of OBT076 in patients with advanced or refractory solid tumors.
Part A, the dose escalation phase:
To explore escalating IV doses to determine the maximum tolerated dose (MTD) of OBT076.
Part B, the expansion phase:
To evaluate the safety and preliminary efficacy of OBT076 administered at or below the MTD in expansion cohorts.
To report on a potential novel immuno-oncology mechanism revealed during the Translational Phase I (NCT04064359) immuno-blood profiling of a chemo-refractory patient treated with OBT076, an experimental CD205-directed ADC.
Clinical response was evaluated and immunological markers (CD45, CD205, CD4, CD8, and PD1) in peripheral blood cells were quantified using flow cytometry.
To evaluates safety, tolerability, PK/PD and preliminary efficacy of OBT076 in solid tumor patients with high expression of target protein CD205 (CAP-CLIA validated centralized IHC test).
Part C: to evaluate the safety and preliminary efficacy of sequential therapy OBT076 followed by anti-PD-1 balstilimab in patients with CD205 positive (2+ in ≥ 50% by IHC) solid tumors.
Medical Condition
The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.
Phase
The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
I
Sex
Female & Male
Age
18+ years
Study Drug
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Study Status
Indicates the current recruitment status or the expanded access status
Recruiting
Requirements information
Inclusion criteria
- Subject is ≥ 18 years of age (at the time of signing the ICF) with non-curative recurrent and/or metastatic solid tumors for which a standard therapy is not available or is no longer effective.
- Subject has histologically and/or cytologically confirmed solid tumors.
- Subject with Breast cancer:
- Subject with hormone-receptor positive (as per local laboratory) recurrent locally advanced or metastatic breast cancer, regardless of HER2 status, must have received at least two prior lines of endocrine therapy in the adjuvant or metastatic setting, either as monotherapy or in combination with targeted therapy
- Subject with recurrent locally advanced or metastatic non-curative HER2 negative breast cancer (based on most recently analyzed biopsy), HER2 status is defined as per ASCO-CAP guidelines as negative, if in situ hybridization test or IHC status is 0, 1+, or 2+.
- Subject with triple negative breast cancer are eligible after at least one prior line of cytotoxic chemotherapy in the metastatic setting.
- Subject with prior adjuvant or neoadjuvant chemotherapy allowed.
- Subject has received a maximum of two prior lines of cytotoxic chemotherapy in the metastatic setting. Subject who received three up to five prior lines of cytotoxic chemotherapy in the metastatic setting are eligible, if the last administration of cytotoxic chemotherapy was at least 12 weeks prior to Cycle 1 Day 1
- Subject has tumor that is positive for CD205 antigen by IHC staining
- Subject has an ECOG performance status of 0-1.
- Subject has radiological documented measurable disease (i.e., at least 1 measurable lesion as per RECIST Version 1.1).
- Subject has adequate organ function
- Subject has adequate bone marrow function
- Subject understands and voluntarily signs an ICD prior to any study-related assessments/procedures are conducted.
- Subject is able to adhere to the study visit schedule and other protocol requirements.
- Subject who is a female of childbearing potential (defined as a sexually mature women, has not undergone hysterectomy (the surgical removal of the uterus) or bilateral oophorectomy (the surgical removal of both ovaries) or 2) has not been naturally postmenopausal for at least 12 consecutive months and is using any adequate form of birth control must:
- Have a negative pregnancy test within 1 week before first dose of study drug.
- Use highly effective method(s) of birth control consistently and correctly during the study and for at least 4 months after the last dose of study drug.
- Agree to not donate eggs (ova, oocytes) for the purposes of assisted reproduction during the study and for at least 4 months after the last dose of study.
- Agree to no plan to breastfeed and no plan to become pregnant during the study and for at least 4 months after the last dose of study drug.
- Subject who is a sexually active male must agree to use a condom, not to donate sperm and have no plans to father a child during the study and for at least 4 months after the last dose of study drug
Exclusion criteria
- Subject has received any chemotherapy within 28 days prior to Cycle 1 Day 1.
- Subject has received any other systemic anticancer therapy within 28 days or 5 half-lives of Cycle 1 Day 1.
- Subject has symptomatic visceral crisis requiring chemotherapy per Investigator judgment for non TNBC.
- Subject with colorectal cancer and pancreatic cancer are not eligible for the study.
- Subject with peritoneal involvement, i.e., peritoneal carcinomatosis, are not eligible for the study.
- Subject has not recovered from the acute toxic effects (CTCAE grade ≤ 1) of prior anticancer therapy, radiation, or major surgery/significant trauma (except alopecia or other toxicities not considered a safety risk for the subject at the Investigator's discretion).
- Subject has had major surgery within 14 days prior to starting study treatment or has not recovered from major side effects.
- Subject has had radiotherapy ≤ 4 weeks prior to starting study drug.
- Subject has a history of, or current symptomatic brain metastasis.
- Subject has any other malignancy within 5 years prior to randomization
- Subject has a known or suspected hypersensitivity or other contraindication to any excipients used in the manufacture of OBT076.
- Subject has significant medical condition, laboratory abnormality, or psychiatric illness that would, in the Investigator's judgment, contraindicate patient participation in the study (e.g., history of thromboembolic event, cardiac dysfunction, chronic pancreatitis, chronic active hepatitis)
- Subject has severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine <7 days before Cycle 1 Day 1
- Subject has any condition that confounds the ability to interpret data from the study.
- Subject is lactating or breastfeeding.
- Subject has a past medical history of or ongoing clinically relevant interstitial lung disease, drug-induced pneumonitis or severe/very severe COPD.
- Subject has active or chronic corneal disorder or Sjogren's syndrome.
- Subject has any ongoing skin disorders not controlled by specific treatment.
- Subject has significant active cardiac disease within the previous 6 months including unstable angina or angina requiring surgical or medical intervention, significant cardiac arrhythmia, or NYHA class 3 or 4 congestive heart failure, or patients with QTc interval >470ms at screening.
- Subject has a known history or current diagnosis of HIV infection, unless on triple antiviral treatment with undetectable viral load.
- Subject who is female of childbearing potential
- Subject who is unable or unwilling to take folic acid or vitamin B12 supplementation.
- Subject with a history of allogeneic organ transplant.
- Subject with grade 3 or 4 immune-related adverse reactions during any prior line of checkpoint inhibitor containing therapy. Patients with immune-related thyroiditis controlled with substitution, or prior asymptomatic lipase increases are eligible for the study.
- Subject with active autoimmune disease or history of autoimmune disease that required systemic treatment within 3 years of the start of study treatment.
- Additional inclusion criteria specific for Part E:
- 1. Patients with stage IV NSCLC or stage III/stage IV urothelial cancer who have progressed on standard treatments or for whom a standard therapy is not available, standard therapy is no longer effective, or who have no satisfactory treatment options.
- Additional exclusion criteria for Part E:
- The presence of any contraindication to gemcitabine as per applicable Summary of Product Characteristics/label.
- Patients with a condition requiring systemic treatment with either corticosteroids (>10 mg daily prednisone equivalent) within the 14 days prior to the first dose of study treatment or another immunosuppressive medication within the 30 days prior to the first dose of study treatment. Inhaled or topical steroids, and adrenal replacement steroid doses )\ mg daily prednisone equivalent) are permitted in the absence of active autoimmune disease.
- Patients with urothelial cancer and any history or current CNS metastasis.
- Patients who were hospitalized during screening for infectious complications or required IV antibiotics in the 14 days prior to Cycle 1 Day 1.
- Patients who presented in the 14 days prior to or on Cycle 1 Day 1 with one or more of the following:
- ANC of <1.5 x 109 cells/L
- Platelets of < 100 x 109 cells/L
- Hemoglobin of < 9 g/dL
- Patients who received G-CSF in the 14 days prior to Cycle 1 Day 1
- Patients who had febrile neutropenia during the previous line of therapy or during the last line of therapy containing cytotoxic chemotherapy.
- Patients who are primary refractory to anti-PD-(L)1 directed therapy.
- Patients with NSCLC and more than 2 prior lines of systemic anti-cancer therapy in the locally-advanced/metastatic disease setting; and who received more than one prior line of cytotoxic chemotherapy in the locally-advanced/metastatic setting.
- Patients with urothelial cancer who received more than 3 prior lines of systemic anti cancer therapy in locally-advanced/metastatic disease setting. Prior neoadjuvant or adjuvanttherapy is not counted.
Clinical Study Information for Healthcare Providers
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Study Locations
Location
Investigator
Status
Condition(s) Treated at Site
Location
START Barcelona
Barcelona, Spain, 08023
Investigator
Tatiana Hernandez Guerrero
Status
Recruiting
Condition(s) Treated at Site
Solid Tumor
Location
START Madrid, Spain (FJD)
Madrid, Spain, 28040
Investigator
Manuel Pedregal Trujillo
Status
Recruiting
Condition(s) Treated at Site
Solid Tumor